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IMMUNOGLOBULIN FC FRAGMENTS
Descriptors Found:
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DeCS
Descriptor
English
:
Immunoglobulin Fc Fragments
Descriptor
Spanish
:
Fragmentos Fc de Inmunoglobulinas
Descriptor
Portuguese
:
Fragmentos Fc das Imunoglobulinas
Synonyms
English
:
Fc Fragments
Fc Immunoglobulins
Tree Number:
D12.776.124.486.485.538.500
D12.776.124.486.485.680.697
D12.776.124.790.651.538.500
D12.776.124.790.651.680.660
D12.776.377.715.548.538.500
D12.776.377.715.548.680.660
Definition
English
:
Crystallizable fragments composed of the carboxy-terminal halves of both
IMMUNOGLOBULIN HEAVY CHAINS
linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the
cell membrane
via FC RECEPTORS, and placental transport). This fragment can be obtained by
digestion
of
immunoglobulins
with the proteolytic enzyme
PAPAIN.
Indexing Annotation
English
:
DF: IG FC
Pharmacological Action:
Immunologic Factors
See Related
English
:
Receptors, Fc
History Note
English
:
2006 (1973)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
poisoning
radiation effects
toxicity
therapeutic use
ultrastructure
urine
Record Number:
22215
Unique Identifier:
D007141
Occurrence in VHL
:
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